Beyond HRT: Your Guide to Non-Hormonal Menopause Treatment Options

HRT is not the right path for every woman. Some have genuine contraindications, others prefer to explore non-hormonal approaches first, and some want to manage specific symptoms without hormones. This post is for all of them. The non-hormonal treatment landscape has changed significantly since 2023. Two new FDA-approved medications have reached the market. The evidence base for lifestyle interventions has matured. Pauza's goal is to provide the most up to date research available, not advocacy for any particular path. FDA-approved non-hormonal medications Neurokinin receptor antagonists — the newest class The most significant development in non-hormonal menopause treatment in recent years is the arrival of a new class of medications: neurokinin receptor antagonists. These drugs work by targeting specific neural pathways in the hypothalamus that become overactive as estrogen declines, driving vasomotor symptoms. Unlike SSRIs or other repurposed medications, these were specifically designed to treat (...)

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